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Single Nucleotide Polymorphism in Deoxyribonuclease I (DNase I, Q222R/rs1053874 A/G) is associated with Systemic Lupus Erythematosus (SLE)

Article scientifique 2022 Anglais

Résumé

Abstract Deoxyribonuclease I (DNase I) is a potential endonuclease enzyme implicated in several immune diseases such as SLE. The objective of this study was to investigate the influence of rs1053874 A/G DNase I polymorphism on SLE susceptibility and to study its influence on serum DNase I levels. The genomic DNA for all participants was genotyped utilizing TaqMan™ assay and Serum DNase I levels were determined by enzyme-linked immunosorbent (ELISA) assay. Individuals with the GA, AA, GA + AA genotypes, and A allele of rs1053874 A/G in the DNase I gene had decreased SLE risk. Also, regression analysis revealed that patients with the genotype "GA + AA" and decreased DNase I levels had decreased risk for prediction of SLE activity (P < 0.05). In Conclusion, The DNase I rs1053874 A/G reduced the incidence of SLE in the Egyptian population. Moreover, “GA + AA” in the same SNP is thought to be an independent predictor of the progression of SLE by reducing serum DNase I levels.

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Zedan, M., Mutawi, T., Salah, M., Attia, Z. (2022). Single Nucleotide Polymorphism in Deoxyribonuclease I (DNase I, Q222R/rs1053874 A/G) is associated with Systemic Lupus Erythematosus (SLE). https://doi.org/10.21203/rs.3.rs-1727269/v1

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Auteur(s)

Mohamed Zedan Thuraya M. Mutawi Mona T. Salah Zeinab R. Attia

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