Personal DNA sequence modification: a potential new modality for gene transmission and therapy as well as mammalians evolution.

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Abstract Objective: Changes in DNA sequence are usually caused by viruses, certain chemicals and radiation as well as by transposons, somatic hyper mutation and errors during meiosis. We can consider gene therapy as an induced DNA sequence changes by inserting certain gene or genes, through viral vectors mainly. Anyhow, many problems met gene therapy like short-lived nature, need for multiple rounds of that therapy, immune response for gene or vector as foreigners, problems with viral vectors and malignancy induction. Wet nurse or foster suckling mother means breastfeeding an infant that is not one's biological offspring which was a job from ancient Egyptians times till the present. Results: Here we show a significant change in DNA sequence in babies after foster mothers suckling compared to their DNA before suckling foster mother suggesting presence of potential factors in foster mother milk which can change DNA sequence in babies before weaning. This may open the door to study milk as a new potential method for gene transmission and therapy. A method, that probably overcome many of problems meeting gene therapy as well as a possible cause for evolution in mammalians if we consider cross nursing during milk feeding from other species before weaning.

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