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Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2

Article scientifique 2020 Anglais

Résumé

Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.

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Kandeil, A., Gomaa, M., Mostafa, A., Shehata, M., Kayed, A., Kutkat, O., Moatasim, Y., Mahmoud, S., Kamel, M., Shama, N., Sayes, M., El‐Shesheny, R., Yassien, M., Webby, R., Kayali, G., Ali, M. (2020). Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2. https://doi.org/10.1371/journal.pone.0241471

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Auteur(s)

Ahmed Kandeil Mokhtar R. Gomaa Ahmed Mostafa Mahmoud Shehata Ahmed E. Kayed Omnia Kutkat Yassmin Moatasim Sara H. Mahmoud Mina Nabil Kamel Noura M. Abo Shama Mohamed El Sayes Rabeh El‐Shesheny Mahmoud A. Yassien Richard J. Webby Ghazi Kayali Mohamed A. Ali

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