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Rebalancing hepatic carbohydrate metabolism: Effects of Dalbergiella welwitschii (Baker) Baker f. (Fabaceae) under diabetic conditions

Article scientifique 2026 Anglais

Résumé

This study evaluated the effects of an alkaloid-rich leaf extract of Dalbergiella welwitschii (Baker) Baker f. on hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats. Diabetes was induced in rats, which were then treated with low (50 mg/kg) and high (100 mg/kg) doses of the extract, or metformin (200 mg/kg), for 20 days. Key hepatic enzymes—glycogen phosphorylase, glucose-6-phosphatase, lactate dehydrogenase, fructose-1,6-bisphosphatase, glycogen synthase, and hexokinase—along with hepatic glycogen and insulin levels were measured. Treatment with the extract significantly restored enzyme activities, increased insulin levels, and enhanced glycogen content. These results indicate that D. welwitschii extract can modulate hepatic carbohydrate metabolism and may have potential therapeutic benefits for diabetes management.

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Ajiboye, B., Onikanni, S., Ekundayo, B., Oladele, I., Lawal, O., Bello, T., Ogedengbe, O., Adedeji, O., Taher, M., Khotib, J., Susanti, D., Okesola, M., Oyinloye, B., Vitalini, S., Iriti, M. (2026). Rebalancing hepatic carbohydrate metabolism: Effects of Dalbergiella welwitschii (Baker) Baker f. (Fabaceae) under diabetic conditions. https://doi.org/10.3934/molsci.2026009

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Auteur(s)

Basiru Olaitan Ajiboye Sunday Amos Onikanni Bidemi Emmanuel Ekundayo Itunu Temitope Oladele Olaolu Ebenezer Lawal Taoheed Olawale Bello Oluwatosin Olalekan Ogedengbe Odunayo Selimot Adedeji Muhammad Taher Junaidi Khotib Deny Susanti Mary Abiola Okesola Babatunji Emmanuel Oyinloye Sara Vitalini Marcello Iriti

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