Editorial: Channel Modulation in Neurodegeneration and Neuroprotection

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Ion channels are critically important for the normal function of the brain and excitable tissues. The 12Research Topic "Channel Modulation in Neurodegeneration and Neuroprotection" focused on the role 13 of ion channel function or dysfunction in neurological and neurodegenerative conditions. Convergent 14 efforts to establish a link between clinical neurology, genetics, loss of function of important proteins 15 and channelopathies in neurological disorders have become an intense area of research interest. Several 16 ion channels have been implicated as important players in these diseases. This research topic therefore 17 includes ten key research articles and two up-to-date review papers in the field of ion channels, their 18 structural features and their proposed modes of action, through the analyses of their structural 19 characteristics, structure-function relationship, therapeutic modulation and neuropharmacology. 20 In summary, this Research Topic contributes to an "in-depth" knowledge of ion channels, their 91 dysregulation and their effects in neurological conditions, opening the way to new attractive research 92 in neuropharmacology, in parallel with the identification of new candidate drugs. We believe that this 93 collection of articles will inspire many researchers and clinicians worldwide to continue working in or 94 enter the field of ion channel research associated with neurological disorders.In

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