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In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two Cameroonian medicinal plants.

Article scientifique 2021 Anglais

Résumé

Abstract Background: Treatment of Candida infections, increasingly difficult due to antifungal drug resistance has drawn attention toward the search for innovative and effective drugs. Results: Essential oils (EOs) from Drypetes gossweileri (DG) stem bark showed activity with MIC value of 62.5 µg/mL against Candida albicans and Candida parapsilopsis, whereas EOs from Pentadiplandra brazzeana (PB) root exhibited MICs of 125 µg/mL and 250 µg/mL against the respective yeasts. The EOs were fungicidal with synergism on C. parapsilopsis and additivity on C. albicans, with 2 to 64-fold drop in MIC values. The MIC combination of 31.25/7.81 µg/mL and 1.95/31.25 µg/mL (DG/PB EOs) required 20 and 18 hours of exposure, respectively to effectively kill 99.9% of the inoculum, this accompanied by alteration of the cell walls and membranes of yeasts. Conclusion: The potency of the EOs combinations indicates further directions in their investigation as potential anticandidal agents.

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Tchinang, T., Foé, F., Keumoe, R., Menkem, E., Boyom, F., Etoa, F. (2021). In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two Cameroonian medicinal plants.. https://doi.org/10.21203/rs.3.rs-289112/v1

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Auteur(s)

Tatiana Flore Kemegni Tchinang Florentine Marie-Chantal Ndoyé Foé Rodrigue Keumoe Elisabeth Zeuko’o Menkem Fabrice Fekam Boyom François‐Xavier Etoa

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