Review of: "Effect of Ethnic Differences in Breast Cancer Presentation and Prognosis in Singapore"
Résumé
Effect of Ethnic Differences in Breast Cancer Presentation and Prognosis in Singapore"Summary:This study investigates the impact of ethnic differences on breast cancer presentation and prognosis in Singapore, particularly focusing on triple-negative breast cancer (TNBC).Using data from the Singapore Cancer Registry (SCR) and the Joint Breast Cancer Registry (JBCR), the study retrospectively analyzes breast cancer patients from 1960 to 2019. Background:Breast cancer is a predominant health concern in Singapore, representing the leading cancer among women.TNBC, though accounting for only 10-15% of all breast cancers, is notably aggressive and linked with poor prognosis.Given Singapore's multi-ethnic population comprising Malays, Chinese, and Indians, the study aims to elucidate the variations in incidence and prognosis of breast cancer among these ethnic groups.Methods:The study utilizes data from the SCR's 50th Monograph and the JBCR's Annual Report 2022.Ethnicity is categorized into Indian, Malay, and Chinese.Dependent variables include incidence, relative risk, median age at diagnosis, mortality, survival, and tumor characteristics.Additionally, survival analysis of 289 TNBC patients at Singapore General Hospital (SGH) was conducted.Results: Malay women, despite having the lowest age-standardized incidence rate (ASIR), exhibited the lowest overall survival (OS) and highest age-standardized mortality rate (ASMR).They were diagnosed at a younger median age (51.3 years)and had the highest rates of grade 3 tumors (56%) and advanced-stage tumors (42%).Among TNBC patients at SGH, Indians showed the poorest OS compared to Malays and Chinese.
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