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RETRACTED ARTICLE: Oxytocin versus a combination of tranexamic acid and ethamsylate in reducing intraoperative bleeding during abdominal myomectomy: a randomized clinical trial

Article scientifique 2023 Anglais

Résumé

OBJECTIVE: Myomectomy is the preferred surgical approach to manage uterine fibroids. However, uterine fibroids are highly vascular tumors and, consequently, extremely susceptible to problems from myomectomy-related hemorrhage. Hence, we aim to compare oxytocin efficacy and safety profile versus tranexamic acid (TA) with ethamsylate for reducing bleeding during myomectomy. METHODS: October 2020 at El-Galaa Teaching Hospital, El Hussein University Hospital, Al-Azhar University Hospitals of Assiut, and Al-Azhar University Hospitals of Damietta. One hundred and eighty patients were enrolled and divided into three groups: group (1) received an injection of 30 IU of oxytocin in 500 ml of normal saline; group (2) received injections of 1 g of TA, 250 mg of Ethamsylate, and 110 ml of normal saline IV; and group (3) received an injection of 110 ml of normal saline IV just before surgical incision. RESULTS: In 180 premenopausal women, oxytocin and TA with ethamsylate had no significant value in lowering intraoperative blood loss compared with the placebo for abdominal myomectomy (666.25 ± 183.03, 630.72 ± 145.83, and 646.67 ± 168.92, respectively (P = 0.506)). Non-significant trends were observed for a reduction in operation time (P = 0.760), intra/postoperative blood transfusion (P = 0.624), hospital stay (P = 0.986), postoperative fever (P = 0.659), and wound infection (P = 1). CONCLUSION: Oxytocin and TA with ethamsylate had no significant value in lowering intraoperative blood loss compared with the placebo for abdominal myomectomy which opens a new question about the role of the use of the hemostatic drug during myomectomy especially in centers with limited resources and had higher rates. TRIAL REGISTRATION: The study was registered on Pan African Clinical Trials Registry with the following number: PACTR202008739887429 and was approved on 24/08/2020.

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Abdou, A., El-Desouky, E., Farag, E., Mohammed, A., Abdelaziz, D., Shaaban, A., Ellaban, M., Elhalim, A., Elsror, A., Marai, A., Abdel-Hakam, F., Abd‐ElGawad, M., Elrashedy, A., Abdelmonem, H., Kamel, M., Afiffi, I., Elsayed, H., Abdelhamed, S., Bosilah, A., Marie, H. (2023). RETRACTED ARTICLE: Oxytocin versus a combination of tranexamic acid and ethamsylate in reducing intraoperative bleeding during abdominal myomectomy: a randomized clinical trial. https://doi.org/10.1186/s12905-023-02549-z

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Auteur(s)

Ahmed Mahmoud Abdou El-Sayed El-Desouky Elsayed Farag Attia Mohammed Doaa Fathy Mohamed Abdelaziz Atallah A. Shaaban Mostafa Mohammed Ellaban Abd Elhalim Mohamed Abd Elhalim Ahmed Gamal Abo Elsror Al-Refaai Abd El-Fattah Marai Faiza Ahmed Abdel-Hakam Mohamed Abd‐ElGawad Asmaa Ahmed Elrashedy Hanaa Abdelmonem Mohamed Abdelmonem Kamel Ibtesam K. Afiffi Hazem Galal Abdelhameed Elsayed Sameh Abdelmoneim Abdelhamed Almandouh H. Bosilah Heba Marie

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