Transferase of mycotoxins in wistar rats treated with aqueous extract of pap consumed in Enugu, Nigeria

Résumé

Food contamination by mycotoxins is a widely recognized global public health issue, particularly in impoverished nations. The objective of this work was to quantify the levels of Aflatoxin and Ochratoxin in a sample of pap consumed in Enugu, Nigeria, an to identify the mycotoxins in the blood of wistar rats that were administered an ageous extract of pap. A total of twenty male Wistar rats were separated into four groups, with five rats each group being administered varying doses of the extract for a duration of two weeks. Concentrations of mycotoxins were determined in both the digested pap and ageous extract using the Enzyme Linked Immunosorbent Assay. Data analysis was conducted using Graphpad Prism Version 8.0 and presented as the mean + standard deviation, with a significance level of p < 0.05. The pap samples contained amounts of Aflatoxin and Ochratoxin of 16.7 + 0.20 and 11.9 + 0.56 ppm, respectively. The serum concentrations of the mycotoxins Aflatoxin (Group A = 0.00 + 0.00, Group B = 5.2 + 1.16, Group C = 5.7 + 2.1, Group D = 8.4 + 2.6 ppm) and Ochratoxin (Group A = 0.00 + 0.00, Group B = 1.7 + 0.58, Group C = 3.5 + 1.9, Group D = 6.1 + 4.3 ppm) for the treated rats increased in a dose-dependent manner. The observed results fell under the acceptable thresholds of mycotoxins in food. The present results indicate that the consumption of pap in Enugu is generally safe. However, it is necessary to remove mycotoxins from it.

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