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A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations

Article scientifique 2017 Anglais

Résumé

Abstract Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. Ktrans, ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known Ktrans and ve values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain Ktrans and ve kinetic trends across algorithms. Algorithms performed well (less than 3% average error) when no noise was present in the DRO. With noise, 87% of Ktrans and 84% of ve algorithm-DRO combinations were generally in the correct order. Low Krippendorff’s alpha values showed that algorithms could not consistently classify patients as above or below the median for a given algorithm at each time point or for differences in values between time points. A majority of the algorithms produced a significant Spearman correlation in ve of the primary gross tumor volume with time. Algorithmic differences in Ktrans and ve values over time indicate limitations in combining/comparing data from distinct DCE-MRI model implementations. Careful cross-algorithm quality-assurance must be utilized as DCE-MRI results may not be interpretable using differing software.

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Ger, R., Mohamed, A., Awan, M., Ding, Y., Li, K., Fave, X., Beers, A., Driscoll, B., Elhalawani, H., Hormuth, D., Houdt, P., He, R., Zhou, S., Mathieu, K., Li, H., Coolens, C., Chung, C., Bankson, J., Huang, W., Wang, J., Sandulache, V., Lai, S., Howell, R., Stafford, R., Yankeelov, T., Heide, U., Frank, S., Barboriak, D., Hazle, J., Court, L., Kalpathy–Cramer, J., Fuller, C. (2017). A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations. https://doi.org/10.1038/s41598-017-11554-w

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Auteur(s)

Rachel Ger Abdallah Mohamed Musaddiq Awan Yao Ding Kimberly Li Xenia Fave Andrew Beers Brandon Driscoll Hesham Elhalawani David A. Hormuth Petra J. van Houdt Renjie He Shouhao Zhou Kelsey B. Mathieu Heng Li Catherine Coolens Caroline Chung James A. Bankson Wei Huang Jihong Wang Vlad C. Sandulache Stephen Y. Lai Rebecca M. Howell R. Jason Stafford Thomas E. Yankeelov Uulke A. van der Heide Steven J. Frank Daniel P. Barboriak John D. Hazle Laurence E. Court Jayashree Kalpathy–Cramer Clifton D. Fuller

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