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The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19

Article scientifique 2021 Anglais

Résumé

BACKGROUND: Several vaccines have been fast-tracked in an attempt to decrease the morbidity and mortality of COVID-19. However, post-exposure prophylaxis has been overlooked in battling COVID-19. MAIN TEXT: Inhaled nitric oxide is a potential tool in post-exposure prophylaxis of COVID-19. It decreases cytosolic calcium levels, which impairs the action of Furin. SARS-CoV-2 uses Furin to replicate in the respiratory tract. SHORT CONCLUSION: Inhaled nitric oxide could decrease the viral load in the upper respiratory tract, abort clinically symptomatic infection, and prevent subsequent complications. Nitric oxide might be a tool for post-exposure chemoprophylaxis in at-risk groups, especially medical personnel.

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AbdelMassih, A., Hozaien, R., Shershaby, M., Kamel, A., Ismail, H., Arsanyous, M., El-Husseiny, N., Khalil, N., Naeem, Y., Fouda, R. (2021). The potential role of inhaled nitric oxide for postexposure chemoprophylaxis of COVID-19. https://doi.org/10.1186/s43141-021-00249-5

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Auteur(s)

Antoine AbdelMassih Rafeef Hozaien Meryam El Shershaby Aya Kamel Habiba‐Allah Ismail Mariem Arsanyous Nadine El-Husseiny Noha M. Khalil Youstina Naeem Raghda Fouda

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