Accès ouvert

Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.

Article scientifique 2020 Anglais

Résumé

Abstract ObjectiveGlutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors associated with blood pressure control in patients with essential hypertension, especially the role of GSTT1 and GSTM1 genes polymorphisms. This cross-sectional study in Burkina Faso consisted of 200 patients with essential hypertension and under treatment. ResultsThis cross-sectional study population consisted of 57.5 % (115/200) of patients with their hypertension under control. No statistically significant difference (p > 0.05) was found between controlled and uncontrolled (SBP and/or DBP) groups for anthropometric and biochemical parameters as well as for GSTT1 or GSTM1 gene polymorphisms. However, current alcohol consumption (OR = 3.04; CI = 1.88 - 6.13; p < 0.001), physical inactivity (OR = 3.07; CI = 1.71 - 5.49; p < 0.001), severity of hypertension (Grade III [OR = 3.79; CI = 2.00 - 7.17; p < 0.001]) and heart damage (OR = 3, 14; CI = 1.59 - 6.02; p < 0.001) were statistically more frequent in uncontrolled essential hypertension group than controlled group.

Citer ce document

SOMBIE, H., Tchelougou, D., Sorgho, P., Kologo, J., Ouattara, A., Yaméogo, S., Zongo, A., Kiendrebeogo, I., Yelemkouré, E., Adoko, E., Yonli, A., Djigma, F., Zabsonré, P., Millogo, H., Simporè, J. (2020). Glutathione S-transferase M1 and T1 Genes Deletion Polymorphisms and Blood Pressure Control Among Treated Essential Hypertensive Patients in Burkina Faso.. https://doi.org/10.21203/rs.3.rs-89342/v1

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Herman Karim SOMBIE Daméhan Tchelougou Pegdwendé Abel Sorgho Jonas Koudougou Kologo Abdoul Karim Ouattara Sakinata Yaméogo Arsène Zongo Isabelle Touwendpoulimdé Kiendrebeogo Edwige Yelemkouré Enagnon Tiémoko Herman Donald Adoko Albert Théophane Yonli Florencia Wendkuuni Djigma Patrice Zabsonré Hassanata Millogo Jacques Simporè

Statistiques

Consultations : 1

Téléchargements : 0