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Cross-species spill-over potential of the H9N2 bat influenza A virus

Article scientifique 2024 Anglais

Résumé

In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.

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El‐Shesheny, R., Franks, J., Kandeil, A., Badra, R., Turner, J., Seiler, P., Marathe, B., Jeevan, T., Kercher, L., Hu, M., Sim, Y., Hui, K., Chan, M., Thompson, A., McKenzie, P., Govorkova, E., Russell, C., Vogel, P., Paulson, J., Peiris, M., Webster, R., Ali, M., Kayali, G., Webby, R. (2024). Cross-species spill-over potential of the H9N2 bat influenza A virus. https://doi.org/10.1038/s41467-024-47635-4

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Auteur(s)

Rabeh El‐Shesheny John Franks Ahmed Kandeil Rebecca Badra Jasmine Turner Patrick Seiler Bindumadhav M. Marathe Trushar Jeevan Lisa Kercher Meng Hu Yul Eum Sim Kenrie P. Y. Hui Michael C. W. Chan Andrew J. Thompson Pamela McKenzie Elena A. Govorkova Charles J. Russell Peter Vogel James C. Paulson Malik J. S. Peiris Robert G. Webster Mohamed A. Ali Ghazi Kayali Richard J. Webby

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