Review of: "Toxicological evaluation of aqueous extracts of Clematis hirsuta and Rhamnus prinoides"
Résumé
Clematis hirsuta leaves and Rhamnus prinoides roots have a long history of medicinal use in Nyeri County, Kenya.However, there is no evidence to back up their safety.The acute and sub-acute[U1] toxicity of Clematis hirsuta aqueous leaf and Rhamnus prinoides aqueous root extracts in Wistar rats was[U2] investigated in this study.Changes in body weight, feed pattern and water consumption were used as toxicity indicators in the acute toxicity study, while changes in weight, biochemical and hematological parameters were used as toxicity indicators in the sub-acute[U3] toxicity study.The data from the acute toxicity study was summarized as mean±standard deviation and analyzed using the unpaired Student's t-test.The data from the sub-acute toxicity study was summarized as mean ± standard deviation and analyzed using Two Way ANOVA and Tukey's post hoc test.The significance level was set at p≤0.05.The results showed that the extracts reduced feed and water consumption in rats but caused no physical signs of toxicity or death, nor did they have any significant effects on weight, biochemical, or hematological parameters when compared to controls (state the control).These findings indicated that oral administration of Clematis hirsuta aqueous leaf and Rhamnus prinoides aqueous root extracts to Wistar rats is generally non-toxic.
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