Anti-inflammation study of cellulose-chitosan biocomposite-based Tetrapleura tetraptera (Taub) dried fruits aqueous extract

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Abstract Nanotechnology is making exceptional progress in the medical field. The development of new systems for the delivery of plant ingredients brings benefits such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocomposites from Tetrapleura tetraptera despite its wide range of ethnopharmacological uses including management of the inflammatory diseases. This study aimed to prepare chitosan and cellulose-based nanocomposite with anti-inflammatory potential. The biocomposite showed an encapsulation efficiency of 69.4%. Their formation was confirmed by a peak at 290 nm in UV-Vis. Infrared spectrophotometry proves the formation of a mixed polysaccharide and polyphenols system. No signs of toxicity and no deaths were found, therefore the lethal dose 50 (LD50) is higher than 2000 mg/kg. The biocomposite has an anti-inflammatory activity in vitro with a maximum inhibition of 99.5% and an anti-inflammatory activity in vivo with a maximum inhibition of 98.7% for a dose of 200 mg/kg. The synthesized biocomposite from the aqueous extract of the fruits of Tetrapleura tetraptera showed an anti-inflammatory property with satisfactory safety.

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