Oxidative stress and inflammatory response of AgNPs and chitosan-coated AgNPs (25nm) via different doses in mice

Résumé

Abstract Objective The cytotoxicity of AgNPs in mice comparatively with chitosan-coated AgNPs. Silver and chitosan–coated AgNPs of average size 25 ± 5 nm, which were prepared and characterized at Nanotech Egypt for Photo-Electronics Methods Male mice were administered with different doses of 25, 50, and 100 mg/kg of both nanoparticles, oxidative stress markers; liver functions, pro-inflammatory cytokines and some tumor markers were measured Results AgNPs significantly increased malondialdehyde and nitric oxide levels. Moreover, it was found that AgNPs significantly increased the levels TNF-α and IL-6 as well as the levels of α-L-fucosidase and arginase and DNA damage measured by comet assay. On the contrary significantly decreased superoxide dismutase and reduced glutathione levels. They also led to deteriorations in serum aminotransferases, alkaline phosphatase and γ-glutamyltransferase levels, chitosan–coated AgNPs reduced the inflammatory caused in hepatic cells. Conclusion Chitosan–coated AgNPs was decreased AgNPs toxicity, by improving the biochemical parameters enrolled in this study, chitosan–coated AgNPs had less cytotoxic effects on liver function, and inflammatory biomarkers.

Citer ce document

Accès au document

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0