Electrochemically-Selective Electrode for Quantification of Dorzolamide in Bulk Drug Substance and Dosage Form

Résumé

Abstract Three smart carbon paste electrodes were fabricated to quantify the dorzolamide hydrochloride DRZ, including conventional carbon paste I, modified carbon paste embedding Silica II, and modified carbon paste embedding β-cyclodextrin III. This study is built on the inserting of DRZ with phosphomolybdic acid to create an electroactive moiety dorzolamide-phosphomolybdate ion exchanger using a solvent mediator dibutylphthalate. The three constructed carbon paste electrodes displayed Nernstian responses and linear concentration ranges with lower detection limits. The vital performance of the created electrodes was verified with in relation to various parameters. The electrodes enhance the selective determination of DRZ in presence of inorganic ions, co-formulated drug in the dosage form timolol maleate and the excipient benzalkonium chloride. The modified carbon paste electrode inclusion Silica was utilized to detect the DRZ in ophthalmic eye drop form utilizing the direct calibration curve and potentiometric titration methods. Satisfactory findings were achieved by comparing to other reported methods.

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