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In Vitro Antisickling Activity of Moringa Oleifera Extracts on Sickle Cells

Article scientifique 2020 Anglais

Résumé

Abstract Background: Sickle cell disease is one of the major haemoglobinopathies affecting African people, in Sudan many children are suffering from this disease. Numerous studies revealed that some medicinal plants have shown an antisickling activity, which may be a new therapeutic way to a range of people who are affected by this disease. Particularly that, chemical treatment is cost effective and has many side effects. The study aimed to evaluate in vitro antisickling effect of Moringa Oliefera on sickle cells.Materials and methods: Using seeds and leaves crude (methanol extract and aqueous extract), the in vitro antisickling activities of Moringa oleifera fractions, were evaluated using erythrocyte cells deoxygenated with 2% sodium metabisulphite. Normal saline was employed as an internal negative control.Results: All extracts revealed high anti sickling activity in deoxygenated erythrocytes (P < 0.05) when compared with the negative control.Conclusions: Findings from the present study suggest the antisickling potential of the seeds and leaves of Moringa oleifera.

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Omer, R., Yousif, N., Fadlalla, T., Elradi, W., Elbasheir, M., Allah, E. (2020). In Vitro Antisickling Activity of Moringa Oleifera Extracts on Sickle Cells. https://doi.org/10.21203/rs.3.rs-32121/v1

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Rayan Hamid Omer Nusiba Abdullah Yousif Toga Abdalazim Fadlalla Wala Eldin Osman Elradi Mohamed Mobarak Elbasheir Elharam Ibrahim Abd Allah

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