Evaluation the effect of Gum Arabic as prophylactic agent against chemotherapy-induced oral mucositis in cancer patients: A clinical trial

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Abstract Several of oral problems such as mucositis, dry mouth and dysphagia associated with cancer therapy have significant impact on the physical status, social, and psychological behavior of cancer patients to varying degrees. The purpose of this research was to investigate the effect of Gum Arabic to prevent chemotherapy-induced oral mucositis in cancer patients. A clinical trial was conducted for a total of 374 cancer patients (14-80 years of age). Patients were categorized into two groups; 190 in the study group and 184 in the control group. The study group, who received chemotherapy were given a dose of 30 grams per day Gum Arabic orally for six weeks, while the control group received only chemotherapy. Essential data concerning the patients were recorded, and the assessment of oral mucositis was carried out weekly for six weeks. This study showed a significant (P = 0.001) reduction in the incidence of chemotherapy-induced oral mucositis in the fourth week and in the sixth week (P = 0.002). This study concluded that the regular administration of Gum Arabic has beneficial effects for cancer patients against oral mucositis induced by chemotherapy. This work registered at ClinicalTrials.gov by the following Identifier number: NCT03348241.

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