Accès ouvert

Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Article scientifique 2022 Anglais

Résumé

Abstract Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a sub-Saharan-African GWAS for lipid traits in the population cross-sectional AWI-Gen cohort (N = 10,603) we report a novel LDL-C association in theGATBregion (P-value=1.56 × 10−8). Meta-analysis with four other African cohorts (N = 23,718) provides supporting evidence for the LDL-C association with theGATB/FHIP1Aregion and identifies a novel triglyceride association signal close to theFHITgene (P-value =2.66 × 10−8). Our data enable fine-mapping of several well-known lipid-trait loci includingLDLR, PMFBP1andLPA. The transferability of signals detected in two large global studies (GLGC and PAGE) consistently improves with an increase in the size of the African replication cohort. Polygenic risk score analysis shows increased predictive accuracy for LDL-C levels with the narrowing of genetic distance between the discovery dataset and our cohort. Novel discovery is enhanced with the inclusion of African data.

Citer ce document

Choudhury, A., Brandenburg, J., Chikowore, T., Sengupta, D., Boua, P., Crowther, N., Agongo, G., Asiki, G., Gómez‐Olivé, F., Kisiangani, I., Maimela, E., Masemola-Maphutha, M., Micklesfield, L., Nonterah, E., Norris, S., Sorgho, H., Tinto, H., Tollman, S., Graham, S., Willer, C., Hazelhurst, S., Ramsay, M. (2022). Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits. https://doi.org/10.1038/s41467-022-30098-w

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Ananyo Choudhury Jean‐Tristan Brandenburg Tinashe Chikowore Dhriti Sengupta Palwendé Romuald Boua Nigel J. Crowther Godfred Agongo Gershim Asiki F. Xavier Gómez‐Olivé Isaac Kisiangani Eric Maimela Matshane Masemola-Maphutha Lisa K. Micklesfield Engelbert A. Nonterah Shane A. Norris Hermann Sorgho Halidou Tinto Stephen Tollman Sarah E. Graham Cristen J. Willer Scott Hazelhurst Michèle Ramsay

Statistiques

Consultations : 1

Téléchargements : 0