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Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities

Article scientifique 2026 Anglais

Résumé

This study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to-ligand ratio. The copper complex shows the highest antibacterial and cytotoxicity efficiency, in addition to a strong binding interactions with DNA. The in-vitro anti-inflammatory and anti-COVID-19 potencies of HL and its complexes were assessed, ranking them as: CuL > NiL > ZnL > VOL > HL.

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Abdel‐Rahman, L., El‐ezz, D., Abdel-Mawgoud, A., Shehata, M., El‐Remaily, M., Abdel‐Hameed, M., Mohamed, S. (2026). Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities. https://doi.org/10.1038/s41598-026-38270-8

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Auteur(s)

Laila H. Abdel‐Rahman Doaa Abou El‐ezz Abdel-Mawgoud Abdel-Mawgoud Mohamed R. Shehata Mahmoud Abd El Aleem Ali Ali El‐Remaily Mohamed Abdel‐Hameed Shaaban Kamel Mohamed

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