COVID-19 and Ebola Reclassification as Novel Acute Immune Deficiency Syndrome (n-AIDS): Potential Curative Role for Immunomodulators.

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Updated, peer reviewed and published at Immunologic Researchhttps://link.springer.com/article/10.1007%2Fs12026-021-09219-y In this manuscript, a suggested reclassification of COVID-19, Ebola virus disease, Nipah virus infection, SARS, and MERS to be considered as a novel acute onset immune dysrhythmia syndrome (n-AIDS) due to altered monocytic, Th1/Th2 as well as cytokines and chemokines balances is provided. n-AIDs is postulated to be the cause of the acute respiratory distress syndrome and multi-inflammatory syndrome described with COVID-19 and potential curative immunomodulators are described for the mentioned diseases as well as for other disorders caused by Th1/Th2 imbalance. Meanwhile, para COVID-19 syndrome is a suggested to describe various immune-related disorders that are associated with SARS CoV-2 infection whether before or after recovery and to embrace a potential of a latent infection that might be discovered later as occurred with Ebola virus disease. Notably, our hypothesis has evolved out of our real-life practice that uses immunomodulatory drugs to manage COVID-19 safely and effectively. Notably, abnormal cytokine, known and yet to be discovered, dependent lymphocyte distraction (clinically manifested by lymphopenia) into (causing ARDS) or away from the lungs (causing multiple inflammatory syndrome) has been early suggested by the author to reason for COVID-19 pathogenesis and we would like to suggest that SARS, MERS and SARS CoV-2; the three virulent RNA corona viruses which emerged in the past two decades, which are also anticipated to be joined by other potentially fatal similar viruses, and Ebola virus disease as well as Nipah virus infection should be considered for a novel immunopathological reclassification that acknowledges their main cause of complications and/or fatalities to be related to their peculiar immune monocytic, Th1/Th2, and potentially other immune cells dysrhythmia that though seems hyperactive, it is practically deficient/incompetent ultimately leading to an acute potentially fatal response; n-AIDS and probable latent effects as recently shown for Ebola and necessitates further investigations to be fully explored for SARS CoV-2; para COVID-19 syndrome.

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