Uterine carcinosarcomas: a clinicopathological report of 8 cases from a low-income country

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Abstract Background Uterine carcinosarcomas (UCS) are rare aggressive biphasic tumors classified as a subtype of high grade uterine carcinomas. However, these tumors have particular histopathological features and clinical behavior with worse prognosis than high grade uterine carcinomas. Their incidence is increasing and more studies are required to elucidate their clinical and histopathological characteristics. Herein we report clinicopathological features of 8 cases of UCS in a low-income country. Cases Presentation: Patients with UCS represent 11.76% of all uterine malignancies with a mean age of 59.75 years (range of 50–65 years). Abdominal pain and metrorrhagia were the main clinical presentation. The epithelial component of UCS was often a serous carcinoma (62.5%) and patients presented with large tumors (mean size of 8.02 cm, range of 5–17 cm), with advanced FIGO stage (stage IV) in 4/8 patients (50%). Follow-up data were available in 4/8 patients among which only one were alive 25 months after the surgical treatment (overall survival of 25%). Conclusion UCS are rare and aggressive uterine tumors with very poor prognosis especially in low-income countries.

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