Association of HLA-DRB1*11 and HLA-DRB1*12 gene polymorphism with COVID-19 in Burkina Faso

Ouédraogo, Alfred Rakissida; Traoré, Lassina; Ouattara, Abdoul Karim; Ouedraogo, Alexis; Zongo, Sidnooma Véronique; Savadogo, Mousso; Lallogo, Tatiana Doriane; Sombié, Herman Karim; Sorgho, Pegdwendé Abel; Ouedraogo, Teega‐Wendé Clarisse; Djigma, Florencia Wendkuuni; Lamien, Assita Sanou; Yonli, Albert Théophane; Lompo, Olga Mélanie; Simporè, Jacques

doi:10.1186/s12920-023-01684-8

Accès ouvert

Association of HLA-DRB111 and HLA-DRB112 gene polymorphism with COVID-19 in Burkina Faso

Article scientifique 2023 Anglais

Résumé

BACKGROUND: The clinical manifestations of coronavirus disease (COVID-19) can vary widely, ranging from asymptomatic to severe, and may be influenced by the host genetic background. The aim of the present study was to determine the frequencies of HLA-DRB1*11 and HLA-DRB1*12 allele polymorphisms and their associations with COVID-19. METHODS: In this cross-sectional study, 198 subjects were enrolled, including 150 COVID-19 positive cases and 48 subjects who tested negative for COVID-19. Participants were recruited from the emergency, intensive care, and infectious diseases departments of the Bogodogo Centre University Hospital (CHU-B) or the routine laboratory of Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA). Genomic DNA was extracted from nasopharyngeal swabs samples and multiplex PCR-SSP was used to detect the HLA-DRB1*11 and HLA-DRB1*12 alleles. The study was approved by CERS (№ 2021-02-033). RESULTS: The positive cases were categorized into 38 asymptomatic (CC+), 60 symptomatic (NC+), and 52 severe cases (SC+). Females were more frequent in the overall study population (53.0%, 105/198) as well as in the negative group's CC- (68.75%, 33/48) and SC+ (57.69%, 30/52 negative groups, whereas males were more frequent in the CC+ (63.16%, 24/38) and NC+ (53.33%, 32/60) groups. The highest mean age was observed in the SC + group. A frequency of 19.19% (38/198) and 14.65% (29/198) was found for the HLA-DRB1*11 and HLA-DRB1*12 alleles, respectively. Individuals carrying the HLA-DRB1*11 allele had an approximately sixfold higher risk of asymptomatic SARS-CoV-2 infection (OR = 5.72 [1.683-19.442], p = 0.005) based on the association analysis. CONCLUSIONS: Altogether, the present study reports high frequency of HLA-DRB1*11 and HLA-DRB1*12 alleles within a population from Ouagadougou, Burkina Faso. The results suggest that individuals carrying the HLA-DRB1*11 allele are more susceptible to COVID-19 infection but may not display symptoms.

Citer ce document

Ouédraogo, A., Traoré, L., Ouattara, A., Ouedraogo, A., Zongo, S., Savadogo, M., Lallogo, T., Sombié, H., Sorgho, P., Ouedraogo, T., Djigma, F., Lamien, A., Yonli, A., Lompo, O., Simporè, J. (2023). Association of HLA-DRB1*11 and HLA-DRB1*12 gene polymorphism with COVID-19 in Burkina Faso. https://doi.org/10.1186/s12920-023-01684-8

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Alfred Rakissida Ouédraogo Lassina Traoré Abdoul Karim Ouattara Alexis Ouedraogo Sidnooma Véronique Zongo Mousso Savadogo Tatiana Doriane Lallogo Herman Karim Sombié Pegdwendé Abel Sorgho Teega‐Wendé Clarisse Ouedraogo Florencia Wendkuuni Djigma Assita Sanou Lamien Albert Théophane Yonli Olga Mélanie Lompo Jacques Simporè

Statistiques

Consultations : 1

Téléchargements : 0