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Prevalence of sexual dimorphism in mammalian phenotypic traits

Article scientifique 2017 Anglais

Résumé

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

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Karp, N., Mason, J., Beaudet, A., Benjamini, Y., Bower, L., Brown, S., Chesler, E., Dickinson, M., Flenniken, A., Fuchs, H., Angelis, M., Gao, X., Guo, S., Greenaway, S., Heller, R., Hérault, Y., Justice, M., Kurbatova, N., Lelliott, C., Lloyd, K., Mallon, A., Mank, J., Masuya, H., McKerlie, C., Meehan, T., Mott, R., Murray, S., Parkinson, H., Ramírez‐Solis, R., Santos, L., Seavitt, J., Smedley, D., Sorg, T., Speak, A., Steel, K., Svenson, K., Obata, Y., Suzuki, T., Tamura, M., Kaneda, H., Furuse, T., Kobayashi, K., Miura, I., Yamada, I., Tanaka, N., Yoshiki, A., Ayabe, S., Clary, D., Tolentino, H., Schuchbauer, M., Tolentino, T., Aprile, J., Pedroia, S., Kelsey, L., Vukobradovic, I., Berberovic, Z., Owen, C., Qu, D., Guo, R., Newbigging, S., Morikawa, L., Law, N., Shang, X., Feugas, P., Wang, Y., Eskandarian, M., Zhu, Y., Nutter, L., Penton, P., Laurin, V., Clarke, S., Lan, Q., Sohel, K., Miller, D., Clark, G., Hunter, J., Cabezas, J., Bubshait, M., Carroll, T., Tondat, S., MacMaster, S., Pereira, M., Gertsenstein, M., Danisment, O., Jacob, E., Creighton, A., Sleep, G., Clark, J., Teboul, L., Fray, M., Caulder, A., Loeffler, J., Codner, G., Cleak, J., Johnson, S., Szoke-Kovacs, Z., Radage, A., Maritati, M., Mianné, J. (2017). Prevalence of sexual dimorphism in mammalian phenotypic traits. https://doi.org/10.1038/ncomms15475

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Auteur(s)

Natasha A. Karp Jeremy Mason Arthur L. Beaudet Yoav Benjamini Lynette Bower Steve D. M. Brown Elissa J. Chesler Mary E. Dickinson Ann M. Flenniken Helmut Fuchs Martin Hrabě de Angelis Xiang Gao Shiying Guo Simon Greenaway Ruth Heller Yann Hérault Monica J. Justice Natalja Kurbatova Christopher J. Lelliott K. C. Kent Lloyd Ann‐Marie Mallon Judith E. Mank Hiroshi Masuya Colin McKerlie Terrence F. Meehan Richard Mott Stephen A. Murray Helen Parkinson Ramiro Ramírez‐Solis Luís Santos John R. Seavitt Damian Smedley Tania Sorg Anneliese O. Speak Karen P. Steel Karen L. Svenson Yuichi Obata Tomohiro Suzuki Masaru Tamura Hideki Kaneda Tamio Furuse Kimio Kobayashi Ikuo Miura Ikuko Yamada Nobuhiko Tanaka Atsushi Yoshiki Shinya Ayabe David Clary Heather Tolentino Michael Schuchbauer Todd Tolentino J Aprile Sheryl Pedroia Lois Kelsey Igor Vukobradovic Zorana Berberovic Celeste Owen Dawei Qu Ruolin Guo Susan Newbigging Lily Morikawa Napoleon Law Xueyuan Shang Patricia Feugas Yanchun Wang Mohammad Eskandarian Yingchun Zhu Lauryl M. J. Nutter Patricia Penton Valerie Laurin Shannon Clarke Qing Lan Khondoker Sohel D. Craig Miller Greg Clark Jane Hunter Jorge Cabezas Mohammed Bubshait Tracy Carroll Sandra Tondat S. MacMaster Monica Pereira Marina Gertsenstein Ozge Danisment Elsa Jacob Amie Creighton Gillian Sleep James D. Clark Lydia Teboul Martin Fray Adam Caulder Jorik Loeffler Gemma Codner James Cleak Sara Johnson Zsombor Szoke-Kovacs Adam Radage Marina Maritati Joffrey Mianné

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