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Th1/Th2 balance and humoral immune response to potential antigens as early diagnostic method of equine Strongylus nematode infection

Article scientifique 2017 Anglais

Résumé

AIM: The aim of this study was to investigate the early diagnosis of strongyle infection based on early changes in Th1 and Th2 cytokines beside the diagnostic accuracy values and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting profiles using prepared strongyles antigens. MATERIALS AND METHODS: (ESC). RESULTS: infected animals, TNF-α/IL-4 balance was approximately equal in apparently healthy group while it was low in moderate and high egg shedder groups. The diagnostic accuracy showed that the higher specificity (46.6%) and prevalence (95.40%) were recorded by CSS and ESC antigens, respectively. However, SDS-PAGE and western blotting profiling proved that the band at molecular weight 25 kDa is exhibited by CSS antigen. CONCLUSION: spp. at the base of serological and molecular investigation.

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Abo-Aziza, F., Hendawy, S., Namaky, A., Ashry, H. (2017). Th1/Th2 balance and humoral immune response to potential antigens as early diagnostic method of equine Strongylus nematode infection. https://doi.org/10.14202/vetworld.2017.679-687

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Auteur(s)

Faten A. M. Abo-Aziza Seham H. M. Hendawy Amira H. El Namaky Heba M. Ashry

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