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Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer

Article scientifique 2021 Anglais

Résumé

OBJECTIVE: Lung cancer is one of the most prevalent cancers and the leading cause of cancer-related deaths worldwide. MicroRNAs regulate more than 60% of human genes, including tumor suppressor genes and oncogenes. Accordingly, they can affect cancer risk. This study aimed to evaluate the role of serum miR-148a as a non-invasive biomarker in non-small cell lung cancer (NSCLC) patients and to assess the correlation between miR-148a and Bcl-2, as one of its target proteins. MATERIALS AND METHODS: A total of 50 newly diagnosed NSCLC cases and 30 apparently healthy controls were recruited in this study. MiR-148a level was measured by TaqMan- Real time RT-PCR assay and Bcl-2 level was measured by ELISA. RESULTS: Significant lower expression of serum miR-148a and higher serum Bcl-2 levels were observed in NSCLC patients as compared to the control group (p.

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Elnaggar, G., El-Hifnawi, N., Ismail, A., Yahia, M., Elshimy, R. (2021). Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer. https://doi.org/10.31557/apjcp.2021.22.6.1949

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Auteur(s)

Ghada Elnaggar Niveen M El-Hifnawi Abeer Ismail Maha Yahia Reham A.A. Elshimy

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