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A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi

Article scientifique 2017 Anglais

Résumé

Controlled human infection model (CHIM) studies have pivotal importance in vaccine development, being useful for proof of concept, pathogenesis, down-selection and immunogenicity studies. To date, however, they have seldom been carried out in low and middle income countries (LMIC), which is where the greatest burden of vaccine preventable illness is found. This workshop discussed the benefits and barriers to CHIM studies in Malawi. Benefits include improved vaccine effectiveness and host country capacity development in clinical, laboratory and governance domains. Barriers include acceptability, safety and regulatory issues. The report suggests a framework by which ethical, laboratory, scientific and governance issues may be addressed by investigators considering or planning CHIM in LMIC.

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Gordon, S., Rylance, J., Luck, A., Jambo, K., Ferreira, D., Manda‐Taylor, L., Bejon, P., Ngwira, B., Littler, K., Seager, Z., Gibani, M., Gmeiner, M., Roestenberg, M., Mlombe, Y. (2017). A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi. https://doi.org/10.12688/wellcomeopenres.12256.1

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Auteur(s)

Stephen B. Gordon Jamie Rylance Amy Luck Kondwani Jambo Daniela M. Ferreira Lucinda Manda‐Taylor Philip Bejon Bagrey Ngwira Katherine Littler Zoe Seager Malick M. Gibani Markus Gmeiner Meta Roestenberg Yohannie Mlombe

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