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Detection of Several Carbapenems Resistant and Virulence Genes in Classical and Hyper-virulent Strains of Klebsiella Pneumoniae Isolated From Hospitalized Neonates and Adults in Khartoum

Article scientifique 2020 Anglais

Résumé

Abstract ObjectiveKlebsiella pneumoniae (K. pneumoniae) involves both community-acquired infections and nosocomial infections. It is responsible for a wide variety of infections including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. We constructed this study to detect several carbapenems resistant and virulence genes in classical and hyper-virulent strains of K. pneumoniae isolated from hospitalized neonates and adults in Khartoum state. ResultsSeventy percent of the isolates were resistant to ceftazidime and 8% to imipenem, 35% were multi-drug resistant, and 7% extensively drug-resistant, all neonatal blood isolates (n=15) were resistant to ceftazidime. entB was the most predominant virulence gene (93.3%), followed by mrkD (78.3%), kfu (60%), K2 (51.7%), magA (18.3%) and rmpA (5%). blaOXA-48 was the most predominant carbapenem-resistant gene (68.3%), followed by blaNDM (10%), blaKPC (8.3%), and blaIMP (3.3%). Eight hyper-virulent strains were positive for blaOXA-48 and two for blaNDM genes.

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Albasha, A., Osman, E., Alhalim, S., Alshaib, E., Al-Hassan, L., Altayb, H. (2020). Detection of Several Carbapenems Resistant and Virulence Genes in Classical and Hyper-virulent Strains of Klebsiella Pneumoniae Isolated From Hospitalized Neonates and Adults in Khartoum. https://doi.org/10.21203/rs.3.rs-29704/v1

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Auteur(s)

Aalaa Mahgoub Albasha Esraa Hassan Osman Saga Abd Alhalim Elianz Alshaib Leena Al-Hassan Hisham N. Altayb

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