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Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial

Article scientifique 2021 Anglais

Résumé

INTRODUCTION: Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data. METHODS: A total of 246 Ugandan adults will be recruited randomized to experimental intervention vs. enhanced treatment control. Intervention participants will receive six weekly group-format stroke risk reduction self-management training sessions, and the controls will receive information on cardiovascular risk. The primary study outcome is systolic B.P. measured at baseline, 13-week, 24 weeks (6 months). Secondary outcomes include other biological and behavioral stroke risk factors. DISCUSSION: The curriculum-guided self-management TargetEd MAnageMent Intervention (TEAM) program is anticipated to reduce the stroke burden in Uganda. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04685408, registered on 28 December 2020.

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Kaddumukasa, M., Najjuma, J., Mbalinda, S., Kaddumukasa, M., Nakibuuka, J., Burant, C., Moore, S., Blixen, C., Katabira, E., Sajatovic, M. (2021). Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial. https://doi.org/10.1371/journal.pone.0251662

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Mark Kaddumukasa Josephine Nambi Najjuma Scovia Nalugo Mbalinda Martin N. Kaddumukasa Jane Nakibuuka Christopher J. Burant Shirley M. Moore Carol Blixen Elly Katabira Martha Sajatovic

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