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The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

Article scientifique 2016 Anglais

Résumé

Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.

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Jin, L., Liu, W., Tian, M., Fan, J., Shi, Y. (2016). The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. https://doi.org/10.1186/s12957-016-0884-7

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Auteur(s)

Lei Jin Wei‐Ren Liu Meng‐Xin Tian Jia Fan Ying–Hong Shi

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