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Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata

Article scientifique 2019 Anglais

Résumé

Abstract Seven pairs of enantiomeric isoflavones (1a/1b–7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.

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Hiep, N., Kwon, J., Hong, S., Kim, N., Guo, Y., Hwang, B., Mar, W., Lee, D. (2019). Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata. https://doi.org/10.1038/s41598-018-36095-8

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Auteur(s)

Nguyen Tuan Hiep Jaeyoung Kwon Sung‐Eun Hong Nahyun Kim Yuanqiang Guo Bang Yeon Hwang Woongchon Mar Dongho Lee

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