Assay of Antibacterial and Antifungal Activity of Silver Nanoparticles Accompanying Different Impurities

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Abstract No doubt that antimicrobial compounds such as antibiotics are the basic tools in clinical medicine. Increase in antimicrobial resistance may cause several human diseases. The potential of drugs and other agents can be improved by using nanoparticles. Wide use of antimicrobial compounds resulted in formation of resistance in microbes. There is demand to look for novel agents for therapy. Novel silver nanoparticles accompanied different impurities were assayed against Streptococcus pyogenes and Staphylococcus aureus (Gram-positive bacteria), Pseudomonas aeruginosa and Proteus mirabilis (Gram-negative bacteria). In addition to Aspergillus niger, A. terrus, Penicillium cluclauni and Rhizopus stolonofer fungi. Four Candida spp. were also assayed: C. krusei, C. famata, C. parapsilosis and C. utiliz. The method which applied in assaying these microorganisms was diffusion method. Dilution method was obtained for the tested nanoparticles to find the minimum inhibitory concentration MIC. The annealing temperature of the tested nanoparticles affected on antifungal and antibacterial activities. It was found that the preparation of nanoparticles at room temperature gave higher activities against tested antimicrobial than that at high temperatures.

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