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Accurate Risk Assessment of Patients with Pathologic T3aN0M0 Renal Cell Carcinoma

Article scientifique 2018 Anglais

Résumé

To develop a more precise risk-stratification system by investigating the prognostic impact of tumor growth within fatty tissues surrounding the kidney and/or renal vein. We conducted a retrospective review of the medical records of 211 patients with a pathologic diagnosis of T3aN0M0RCC among 4,483 renal cell carcinoma (RCC) patients from February 1988 to December 2015 according to the number of T3a pathologies-extrarenal fat invasion (EFI) and/or renal venous invasion (RVI). During a mean follow-up duration of 38.8 months, the patients with both pathologies (EFI + RVI) had lower recurrence free survival (RFS) rate than those with only a single pathology (p = 0.001). Using multivariable Cox regression analysis, the presence of both factors was shown to be an independent predictor of RFS (HR = 1.964, p = 0.032); cancer specific survival rate was not different among patients with EFI and/or RVI. Patients with pathologic T3aN0M0 RCC presenting with both EFI and RVI were at an increased risk of recurrence following nephrectomy. Therefore, pathologic T3a RCC could be sub-divided into those with favorable and unfavorable disease according to presence of EFI and/or RVI pathologies.

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Oh, J., Lee, J., Song, B., Lee, H., Lee, S., Byun, S., Lee, S., Hong, S. (2018). Accurate Risk Assessment of Patients with Pathologic T3aN0M0 Renal Cell Carcinoma. https://doi.org/10.1038/s41598-018-32362-w

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Auteur(s)

Jong Jin Oh Jung Keun Lee Byung Do Song Hakmin Lee Sangchul Lee Seok‐Soo Byun Sang Eun Lee Sung Kyu Hong

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