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Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases

Article scientifique 2017 Anglais

Résumé

Purpose: To determine the association between Cystatin C (Cys C) levels and the interaction of pulmonary tuberculosis (PTB) with chronic diseases (CD).Methods: Participants (n = 356) were selected randomly from The First Affiliated Hospital of Wannan Medical College, China, and divided into 4 groups: normal control group (n = 80), PTB group (n = 98), chronic disease group (n = 146), and PTB combined with chronic disease group (PTB+CD, n = 31). The investigation included information on demographics and analysis of blood samples for Cys C, liver function, renal function, blood glucose and other biochemical indices.Results: The highest level of Cys C was obtained in PTB + CD group. Before and after adjusting eGFR, there was no association between Cys C and PTB or/and chronic disease. However abnormal levels of Cys C were significantly higher in PTB+CD group after adjusting eGFR (OR = 4.014, p = 0.0125).Conclusion: Higher levels of Cys C may be associated with chronic diseases co existing with PTB.Keywords: Cystatin C, Pulmonary tuberculosis, Chronic diseases, Inflammation

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Wu, H., Xu, J., Wen, Y., Xia, D., Liu, M., Ma, J., Wu, Z., Dong, H. (2017). Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases. https://doi.org/10.4314/tjpr.v16i8.34

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Huan Wu Jialing Xu Yufeng Wen Dan Xia Mengxue Liu Jun Ma Zewei Wu Hua Dong

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