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Pre-Pandemic SARS-CoV-2 Potential Natural Immunity Among Population of Central Africa

Article scientifique 2021 Anglais

Résumé

Abstract More than a year after the emergence of COVID-19, significant regional differences in terms of morbidity persist, showing lower incidence rates in central Africa. The work reported here aims to test for a pre-pandemic natural immunity among populations in this region. To identify such pre-existing immunity, sera samples collected before the emergence of COVID-19 were tested to detect IgG antibodies reacting against SARS-CoV-2 proteins of major significance. Sera samples from blood donors of France were used as control. The results showed a statistically significant difference for antibodies prevalence between the samples collected in central Africa and the control samples. Our results suggest that in the central African sub-region the populations have been potentially pre-exposed before the COVID-19 pandemic to the antigens of a SARS-CoV-2-like virus.

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Souris, M., Tshilolo, L., Parzy, D., Ingoba, L., Ntoumi, F., Kamgaing, R., Mbongi, D., Phoba, B., Tshilolo, M., Mbungu, R., Sosso, M., Fainguem, N., Morand, P., Gonzalez, J. (2021). Pre-Pandemic SARS-CoV-2 Potential Natural Immunity Among Population of Central Africa. https://doi.org/10.21203/rs.3.rs-588697/v1

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Auteur(s)

Marc Souris Léon Tshilolo Daniel Parzy Line Lobaloba Ingoba Francine Ntoumi Rachel Kamgaing Destin Mbongi Baltazar Phoba Marie-Anasthasie Tshilolo René Mbungu Martin Samuel Sosso Nadine Fainguem Pierre Morand Jean‐Paul Gonzalez

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