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New Hosts of The Lassa Virus

Article scientifique 2016 Anglais

Résumé

Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.

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Olayemi, A., Cadar, D., Magassouba, N., Obadare, A., Kourouma, F., Oyeyiola, A., Igbokwe, J., Rieger, T., Bockholt, S., Jerome, H., Schmidt‐Chanasit, J., Garigliany, M., Lorenzen, S., Igbahenah, F., Fichet, J., Ortsega, D., Omilabu, S., Günther, S., Fichet-Calvet, É. (2016). New Hosts of The Lassa Virus. https://doi.org/10.1038/srep25280

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Auteur(s)

Ayodeji Olayemi Dániel Cadar N’Faly Magassouba Adeoba Obadare Fodé Kourouma Akinlabi Oyeyiola Joseph Igbokwe Toni Rieger Sabrina Bockholt H. Kim Jerome Jonas Schmidt‐Chanasit Mutien‐Marie Garigliany Stephan Lorenzen Felix Igbahenah Jean-Nicolas Fichet Daniel Ortsega Sunday Omilabu Stephan Günther Élisabeth Fichet-Calvet

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