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Spinal diffuse midline glioma: An unusual case presentation

Article scientifique 2024 Anglais

Résumé

Primary spinal cord neoplasms are rare, accounting for 1% of paediatric central nervous system tumours. The majority of which are low-grade gliomas (LGG). A teenage male presented with rapidly progressive lower limb paralysis. He subsequently underwent a near-total resection of an intramedullary thoracic tumour. Although the initial histopathology report suggested a LGG, closer review of the morphology and immunohistochemical staining revealed a diffusely infiltrating high-grade astrocytoma. Methylation profiling later confirmed a H3K27M-mutated spinal DMG. He underwent spinal radiation to the tumour bed soon after surgery but succumbed to his disease 8 days after completing radiation, and 3 months after presentation. Conclusion: Spinal DMGs are rare, can lead to diagnostic challenges and have a poor prognosis.

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Beringer, N., Bennett, K., Demopoulos, D., Reynders, M., Doedens, L., Tshite, F., Pearce, D., Gani, R., Byl, D., Ramiah, D., Boshoff, P., Profyris, C., Ouma, J., Joshi, A., Bailey, S. (2024). Spinal diffuse midline glioma: An unusual case presentation. https://doi.org/10.4102/sajo.v8i0.306

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Auteur(s)

Nadia Beringer Kate G. Bennett Despina Demopoulos Marelize Reynders Linda G. Doedens Felicia Tshite Deborah Pearce Raazik Gani Dawn-Lee Van der Byl Duvern Ramiah P E Boshoff Christos Profyris John Ouma Abhijit Joshi Simon Bailey

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