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Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo

Article scientifique 2021 Anglais

Résumé

BACKGROUND: The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order to fill the knowledge gap in the field in Togo, the main objective of this study was to determine the prevalence of pre-cancerous lesions of the cervix and HR-HPV genotypes among Togolese women. METHODS: Samples were collected from 240 women by introducing a swab in the cervix. Then, the screening of precancerous cervical lesions using the visual inspection with acetic acid and lugol (VIA / VIL) was conducted. The HR-HPV genotypes were characterised by real-time multiplex PCR. RESULTS: Out of 240 women recruited, 128 (53.3%) were infected by HR-HPV. The most common genotypes were HPV 56 (22.7%), followed by HPV 51 (20.3%), HPV 31 (19.5%), HPV 52 (18.8%) and HPV 35 (17.2%). The least common genotypes were HPV 33 (2.3%) and HPV 16 (2.3%). Among the women, 1.3% (3/240) were positive to VIA/VIL. CONCLUSION: This study allowed HR-HPV genotypes to be characterised for the first time in Lomé, Togo. This will help in mapping the HR-HPV genotypes in West Africa.

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Kuassi-Kpede, A., Dolou, E., Zohoncon, T., Traore, I., Katawa, G., Ouédraogo, R., Traoré, E., Bado, P., Ouedraogo, T., Djigma, F., Karou, S., Simporè, J. (2021). Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo. https://doi.org/10.1186/s12879-021-05956-5

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Auteur(s)

Akouélé P. Kuassi-Kpede Essolakina Dolou Théodora Mahoukèdè Zohoncon Ina Marie Angèle Traore Gnatoulma Katawa Rogomenoma Alice Ouédraogo Esther Mah Alima Traoré Prosper Bado Teega‐Wendé Clarisse Ouedraogo Florencia Wendkuuni Djigma Simplice Damintoti Karou Jacques Simporè

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