Current State of Resistance to Antibiotics of Last-Resort in South Africa: A Review from a Public Health Perspective

Résumé

A review of the literature was undertaken to delineate the current level and mechanisms of resistance to carbapenems, colistin and tigecycline in South Africa. Thirty-two English publications and 32 National Institute of Communicable Diseases (NICD) communiqués identified between early January 2000 and 20th May, 2016 showed substantial reports of NDM (n=860), OXA-48 (n=584), VIM (n=131) and IMP (n=45) carbapenemases within this period, mainly in Klebsiella pneumoniae (n=1138), Acinetobacter baumannii (n=332), Enterobacter cloacae (n=201) and Serratia marcescens (n=108). Colistin and tigecycline resistance was prevalent among K. pneumoniae, A. baumannii, S. marcescens and E. cloacae. The first mcr-1 colistin resistance gene to be detected in South Africa was reported in E. coli from livestock as well as from hospitalized and out patients. There are increasing reports of NDM and OXA-48 carbapenemases among Enterobacteriaceae and A. baumannii in South Africa. Mcr-1 is now present in South African patients and livestock. Resistance to carbapenems, colistin and tigecycline restricts infection management options for clinicians.

Citer ce document

Accès au document

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Statistiques

Consultations : 2

Téléchargements : 0