Etudes biochimique, hématologique et histologique du sulfate de cadmium chez les rats WISTAR

Résumé

Metallic trace elements such as lead, mercury and cadmium are known to cause seriouspublic health issues. Pollution with cadmium is very worrying in Ivory Coast. Studies understaken in Ivory Coast within the framework activities named environmental study and monitoring helped to understand the level of sediment and soil pollution in market farming. The LD50 of cadmium sulfate found was 200 mg/kg of body weight. The wistar rats were contaminated with cadmium sufate by cramming during 30 days with 1/50th, 1/40th , 1/30th , 1/20th , 1/10th of the LD50 corresponding to 4; 5; 6,66; 10 and 20 mg/kg of body weight. The result revealed a significant loss in rat body weight in comparison to the control group ( males and females). The level of Aspartate aminotransferase and Alanine transaminase increased in males and females animals (p<0,05). There was a significant increase in the level of creatinemia no significant and uremia significant between the test and the control groups. In contrast, the level of bilirubine decreased in both male and female animal. For cholesterol, a clear reduction was observed but remains nonsignificant. Compared to the hematologic parameters, cadmium caused an increase in the white blood cell, a decrease in the red blood cells and haemoglobin in both males and females. The results showed that cadmium caused a renal insufficiency damage, anaemia and a disturbance in the spleen operating process in rats.

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