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Genome sequencing reveals existence of SARS-CoV-2 B.1.1.529 variant in Egypt

Article scientifique 2022 Anglais

Résumé

BACKGROUND: Several SARS-CoV-2 variants with increased transmissibility and/or potential immune escape have emerged and rapidly spread worldwide. Ongoing surveillance analyses are performed worldwide to designate new variants of concern (VOC) of coronavirus. MAIN TEXT: This report identifies the first Egyptian patient with a confirmed SARS-CoV-2 omicron variant. The patient showed positivity on reverse transcriptase-polymerase chain reaction and full genome sequencing was performed to confirm the variant. The mutations found in the variant were compared with the GISAID reference strain hCoV-19/Wuhan/WIV04/2019. Genome BLAST showed the highest similarity to omicron variants isolated in South Africa. Phylogenetic analysis revealed that the variant belongs to the 21K clade. CONCLUSIONS: The study indicates the importance of information-sharing among global public health partners. Moreover the importance of implementation of full genome sequencing to rapidly identify and track the new SARS-CoV-2 variants.

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Ismail, G., Abdelghaffar, H., Seadawy, M., El-Hosseny, M., Gad, A., Ageez, A., Elshafei, A., Mohammed, S., Ali, M., El-Ashry, M. (2022). Genome sequencing reveals existence of SARS-CoV-2 B.1.1.529 variant in Egypt. https://doi.org/10.1186/s43141-022-00352-1

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Ghada Ismail Hossam Abdelghaffar Mohamed G. Seadawy Mostafa F. El-Hosseny Ahmed F. Gad Amr Ageez Ahmed Mohamed Kamal Elshafei Shereen Saeed Mohammed Marym Saied Ali Marwa El-Ashry

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