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Alarming rate of transmitted drug resistance mutations and genetic diversity in newly HIV-1-infected patients in Benin

Article scientifique 2020 Anglais

Résumé

Abstract BackgroundSeventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Methods353 plasma samples were collected between October and December 2017 in nineteen facilities care in Benin from HIV-1 positive and ARV naive individuals. Pol (protease + partial RT) region was amplified and sequenced in 248 samples.ResultsDrug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with predominance of mutations directed to NNRTIs drugs (24/248; 10%).Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients.ConclusionsOur study showed a high primary drug resistance rate and a complex genetic diversity. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

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Tchiakpé, E., Kêkê, R., Vidal, N., Ahoussinou, C., Sekpe, O., Dagba, H., Gbaguidi, E., Tonoukouen, C., Afangnihoun, A., Bachabi, M., Gangbo, A., Harrigan, R., Diop‐Ndiaye, H., Touré‐Kâne, C. (2020). Alarming rate of transmitted drug resistance mutations and genetic diversity in newly HIV-1-infected patients in Benin. https://doi.org/10.21203/rs.2.24292/v1

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Edmond Tchiakpé René Kpèmahouton Kêkê Nicole Vidal Clément Ahoussinou Olga Sekpe Hermione G Dagba Eric Gbaguidi Conrad Tonoukouen Aldric Afangnihoun Moussa Bachabi Armande F Gangbo Richard Harrigan Halimatou Diop‐Ndiaye Coumba Touré‐Kâne

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