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Pain across the lifespan: global and regional reference curves from 6.1 million individuals in 118 countries

Article scientifique 2026 Autre

Résumé

Abstract Pain is the leading cause of disability worldwide, yet no population-based reference exists against which individual cohorts, clinical populations, or countries can be benchmarked. Here, we harmonised individual-level self-reported pain data from 6,075,021 participants across 894 population-based data sources in 118 countries to establish global reference trajectories of pain across the lifespan, implemented in an open-access benchmarking platform. Pain prevalence ranged from 2.5% for facial pain to 45.0% for back pain, was consistently higher in women across all eleven anatomical sites (risk ratio range 1.09 to 1.83), and increased most steeply before age 55 years. Contrary to existing estimates that generally project higher prevalence of pain conditions in higher Human Development Index (HDI) regions, we found that individuals in the lowest HDI countries experienced nearly twice the late-life prevalence of any bodily pain compared with those in the highest (risk difference 31.8 percentage points [95% CI 30.1–33.6]). Globally, 18.3% of site-specific pain burden was attributable to three modifiable risk factors (smoking, obesity, and low income) but this varied from 12.6% in sub-Saharan Africa to 27.1% in eastern Europe, indicating that the drivers of pain in lower-HDI settings remain poorly characterised.

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Fillingim, M., Tanguay-Sabourin, C., Neuert, L., Zare, A., Norman, J., Guglietti, G., Hobeika, L., Ayorinde, A., Salimzadeh, A., Jamshidi, A., Tehrani‐Banihashemi, A., Olaya, B., Mbenza, B., Oladeji, B., Penninx, B., Paudyal, B., Melo, C., Berna-Renella, C., Humberg, C., Pascal, C., Smith, E., VanDenKerkhof, E., Giltay, E., García‐Esquinas, E., Parlindungan, F., Abbasi, F., Artalejo, F., Jones, G., Slade, G., Bouziri, H., Flor, H., Iso, H., Gilron, I., Uthman, I., Peláez-Ballestas, I., Nzambi, J., Ayuso‐Mateos, J., Haro, J., Wager, J., Souza, J., Nakamura, K., Yamada, K., Rau, L., Talih, M., Beasley, M., Dueñas, M., Zins, M., Miret, M., Wake, M., Pratama, M., Almalki, M., Chaaya, M., Anshory, M., Kondo, N., Moghadam, N., Mansor, N., Alsaed, O., Keeratisiroj, O., Gureje, O., Kurniari, P., Noormohammadpour, P., Lebughe, P., Elzahaf, R., Kordi, R., Lucas, R., Bhandari, R., Hidayat, R., Samreen, S., Al-Emadi, S., Roknsharifi, S., Inoue, S., Adhikari, S., Wibowo, S., Sharma, S., Villeneuve, S., Tabuchi, T., Khursheed, T., Yamato, T., Jackson, T., Santos, V., Siritaratiwat, W., Liu, X., Liu, Z., Banaschewski, T., Barker, G., Bokde, A., Brühl, R., Desrivières, S., Gowland, P., Grigis, A., Heinz, A., Lemaitre, H., Martinot, J., Martinot, M., Artiges, É., Nees, F., Orfanos, D., Paus, T., Poustka, L., Smolka, M. (2026). Pain across the lifespan: global and regional reference curves from 6.1 million individuals in 118 countries. https://doi.org/10.64898/2026.04.21.26351327

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Auteur(s)

Matt Fillingim Christophe Tanguay-Sabourin Lindsay Neuert Azin Zare Jax Norman Gianluca V. Guglietti Lise Hobeika Abimbola Ayorinde Ahmad Salimzadeh Ahmad-reza Jamshidi Arash Tehrani‐Banihashemi Beatriz Olaya Benjamin Longo Mbenza Bibilola Oladeji Brenda W.J.H. Penninx Buddhi Prasad Paudyal Caique de Melo Chantal Berna-Renella Clarissa Humberg Claude-Pierre Pascal Elisa Smith Elizabeth G. VanDenKerkhof Erik J. Giltay Esther García‐Esquinas Faisal Parlindungan Fatima Qayyum Abbasi Fernando Rodríguez Artalejo Gareth T. Jones Gary Slade Hanifa Bouziri Herta Flor Hiroyasu Iso Ian Gilron Imad Uthman Ingris del Pilar Peláez-Ballestas J P D Nzambi José Luís Ayuso‐Mateos Josep María Haro Julia Wager Juliana Barcellos de Souza Kazutoshi Nakamura Keiko Yamada Lisa‐Marie Rau Makram Talih Marcus Beasley María Dueñas Marie Zins Marta Miret Melissa A Wake Mirza Zaka Pratama Mohammad Almalki Monique Chaaya Muhammad Anshory Naoki Kondo Navid Moghadam Norma Mansor Omar Alsaed Orawan Keeratisiroj Oye Gureje Pande Ketut Kurniari Pardis Noormohammadpour Pierrot Lebughe Raga A. Elzahaf Ramin Kordi Raquel Lucas Rashmi Parekh Bhandari Rudy Hidayat Saba Samreen Samar Al-Emadi Shima Roknsharifi Shinsuke Inoue Sudeep Adhikari Suryo Anggoro Kusumo Wibowo Sweekriti Sharma Sylvia Villeneuve Takahiro Tabuchi Tayyeba Khursheed Tie Parma Yamato Todd Jackson Veronica Souza Santos Wantana Siritaratiwat Xianchen Liu Zhen-Zhen Liu Tobias Banaschewski Gareth J. Barker Arun L.W. Bokde Rüdiger Brühl Sylvane Desrivières Penny Gowland Antoine Grigis Andreas Heinz Herve Lemaitre Jean-Luc Martinot Marie‐Laure Paillère Martinot Éric Artiges Frauke Nees Dimitri Papadopoulos Orfanos Tomáš Paus Luise Poustka Michael N. Smolka

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