COVID-19, SARS and MERS potential reclassification as an acute immunodeficiency syndrome.

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In this manuscript, a suggested reclassification of COVID-19, Ebola virus disease, Nipah virus infection, SARS, and MERS to be considered as a novel acute onset immune dysrhythmia syndrome (n-AIDS) due to altered monocytic, Th1/Th2 as well as cytokines and chemokines balances is provided. n-AIDs is postulated to be the cause of the acute respiratory distress syndrome and multi-inflammatory syndrome described with COVID-19 and potential curative immunomodulators are described for the mentioned diseases as well as for other disorders caused by Th1/Th2 imbalance. Meanwhile, para COVID-19 syndrome is a suggested to describe various immune-related disorders that are associated with SARS CoV-2 infection whether before or after recovery and to embrace a potential of a latent infection that might be discovered later as occurred with Ebola virus disease.

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