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Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife

Article scientifique 2019 Anglais

Résumé

Tuberculosis (TB) in humans is a global public health concern and the discovery of animal cases of Mycobacterium tuberculosis (Mtb) infection and disease, especially in multi-host settings, also has significant implications for public health, veterinary disease control and conservation endeavours. This paper describes a fatal case of Mtb disease in a free-ranging African elephant (Loxodonta africana) in a high human TB burden region. Necropsy revealed extensive granulomatous pneumonia, from which Mtb was isolated and identified as a member of LAM3/F11 lineage; a common lineage found in humans in South Africa. These findings are contextualized within a framework of emerging Mtb disease in wildlife globally and highlights the importance of the One Health paradigm in addressing this anthroponotic threat to wildlife and the zoonotic implications.

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Miller, M., Buss, P., Roos, E., Hausler, G., Dippenaar, A., Mitchell, E., Schalkwyk, L., Robbe‐Austerman, S., Waters, W., Sikar-Gang, A., Lyashchenko, K., Parsons, S., Warren, R., Helden, P. (2019). Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife. https://doi.org/10.3389/fvets.2019.00018

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Auteur(s)

Michele A. Miller Peter Buss Eduard O. Roos Guy Hausler Anzaan Dippenaar Emily Mitchell Louis van Schalkwyk Suelee Robbe‐Austerman W. Ray Waters Alina Sikar-Gang Konstantin P. Lyashchenko Sven D.C. Parsons Robin M. Warren Paul D. van Helden

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