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The relationship between miR-340 and NOD2 may play an important role in Streptococcus pneumoniae-induced meningitis

Article scientifique 2022 Anglais

Résumé

Abstract Bacterial meningitis is a serious infection of the central nervous system in children, with a high mortality rate of 12 % - 35 %. Two-thirds of bacterial meningitis cases in Europe and the United States are caused byStreptococcus pneumoniae. In this study, the overexpression of miR-340 and the knockdown of NOD2 could attenuate the microglial inflammation induced byStreptococcus pneumoniaeand improve the nerve function inStreptococcus pneumoniae-induced meningitis mice. In contrast, inhibited miR-340 and overexpression of NOD2 had the opposite effects. Dual-luciferase reporter assay and recovery experiments showed that miR-340 could reduce the microglial inflammation induced byStreptococcus pneumoniaeand improve the neurological damage caused byStreptococcus pneumoniaewith regulating the expression of NOD2. MiR-340 and NOD2 may become the site of targeted therapy forStreptococcus pneumoniaemeningitis.

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Wang, L., Liu, X., Kang, L., Ma, K., Li, Y. (2022). The relationship between miR-340 and NOD2 may play an important role in Streptococcus pneumoniae-induced meningitis. https://doi.org/10.21203/rs.3.rs-1917943/v1

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Auteur(s)

Lin Wang Xianghong Liu Lili Kang Kai Ma Yanfang Li

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