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The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

Article scientifique 2019 Anglais

Résumé

OBJECTIVE: Gene-environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. RESULTS: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).

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Womersley, J., Clauss, L., Varathan, O., Engelbrecht, S., Hemmings, S., Seedat, S., Spies, G. (2019). The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. https://doi.org/10.1186/s13104-019-4869-9

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Auteur(s)

Jacqueline S. Womersley Lara Bianka Clauss Olivette Varathan Susan Engelbrecht Sian Hemmings Soraya Seedat Georgina Spies

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