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Novel Predictors Of Early Atherosclerosis In Non Alcoholic Fatty Liver Disease

Article scientifique 2022 Anglais

Résumé

Abstract Background: Non alcoholic fatty liver disease is regarded the most relevant liver disease of the twenty-first century, affecting at least one third of the general population. NAFLD is associated with increased mortality due to cardiovascular disease (CVD) and cancer. The carotid intimal media thickness (CIMT), mean platelet volume (MPV) and endocan level, could be markers for generalised atherosclerotic burden and endothelial dysfunction. Aims: To evaluate the association between non alcoholic fatty liver disease and early atherosclerosis by measuring CIMT, mean platelet volume (MPV) and endocan level, as markers of endothelial dysfunction, in NAFLD patients. Methods: This cross –sectional study included 50 patients who divided into two groups; group I included 25 subjects with NAFLD and group II included 25 healthy subjects. Complete blood count with mean platelet volume (MPV), Liver profile, Lipid profile, Fasting blood glucose level and 2 hour postprandial, Kidney function test, Serum concentrations of endocan were measured for all patients. NAFLD fibrosis score (NFS) was calculated. Abdominal ultrasonography and Carotid ultrasound scan for measurement of CIMT were performed. Results: Serum endocan levels, MPV and CIMT were significantly higher (p<0.005) in NAFLD patients (0.6, 9.3±1.2 and 0.9±0.3 respectivly) than healthy subjects (0.1, 8.1±0.6 and 0.6±0.1 respectively). The analysis of diagnostic performance of these factors revealed that they have good sensitivity and specificity in prediction of endothelial dysfunction with AUC (0.950, 0.844 and 0.849 respectivly). Conclusions:Serum endocan levels, MPV and CIMT could be considered as good predictors of endothelial dysfunction and therefore early detection of subclinical atherosclerosis in NAFLD patients.

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Abdulaziz, B., Bendary, A., Thabet, A., Behery, E., Salah, M., rashad, g. (2022). Novel Predictors Of Early Atherosclerosis In Non Alcoholic Fatty Liver Disease. https://doi.org/10.21203/rs.3.rs-2172643/v1

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Badawy A. Abdulaziz Ahmed Bendary Aida Thabet Eman Gamal Behery Mona Salah ghadeer rashad

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