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UL 16 Binding Protein 3 Gene Expression: Does It Have an Association With Alopecia Areata?

Article scientifique 2020 Anglais

Résumé

Abstract ObjectiveAlopecia Areata is one of the most widespread autoimmune diseases affecting both sexes of all ages and across all ethnic individuals. Genetics is considered to be a valuable tool for gaining insight into the disease’s pathogenesis. Association with UL 16 Binding Protein (ULBP) genes has been detected with autoimmune disorders.This study aimed to detect UL-16 Binding Protein -3 (ULBP3) gene expression levels in cases with AA and to correlate those levels with the clinical course of the disease.This study included 85 subjects: 55 patients with AA and 30 age- and sex-matched healthy controls. The expression level of ULBP3 mRNA was estimated using Real-Time Polymerase Chain Reaction (RT-PCR).Results Levels of ULBP3 mRNA in cases were significantly higher in patients with AA in comparison with controls. Also, there were significant correlations between ULBP3 mRNA levels and age of patients and disease duration in years. ULBP3 upregulation in AA enforces the theory that postulates the autoimmune nature of AA and ULBP3 may be involved in AA pathogenesis and its progression.

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Azmy, R., Maraee, A., Amer, E., Tayel, N., Shehata, W. (2020). UL 16 Binding Protein 3 Gene Expression: Does It Have an Association With Alopecia Areata?. https://doi.org/10.21203/rs.3.rs-94400/v1

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Rania Azmy Alaa Hassan Maraee Eman Amer Nermin Tayel Wafaa Ahmed Shehata

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